An intermediate cartridge is a rifle/carbine cartridge that has significantly greater power than a pistol cartridge but still has a reduced muzzle energy compared to fully powered cartridges (such as the .303 British, 7.62×54mmR, 7.92×57mm Mauser, 7.7×58mm Arisaka, .30-06 Springfield, or 7.62×51mm NATO), and therefore is regarded as being "intermediate" between traditional rifle and handgun calibers.

As their recoil is significantly reduced compared to full-power cartridges, fully automatic rifles firing intermediate cartridges are relatively easy to control. However, even though they are less powerful than a traditional full-power cartridge, the external ballistics are still sufficient for an effective range of 300–600 metres (330–660 yd), which covers most typical infantry engagement situations in modern warfare. This allowed for the development of the assault rifle, a type of versatile selective fire small arms that is lighter and more compact than traditional battle rifles that fire full-power cartridges.

Early intermediate cartridges to see service were the German 7.92×33mm Kurz used in the StG 44 and the .30 Carbine used in the American M2 select fire carbine during the late years and closing days of World War II.

With the data collected during World War II and the Korean War, the benefits of intermediate cartridges became apparent. This resulted in the development of "modern" cartridges such as the Soviet 7.62×39mm M43 (used in the SKS, AK-47 and AKM). Later an international tendency emerged towards relatively small-sized, lightweight, high-velocity Intermediate military service cartridges. Cartridges like the American 5.56×45mm M193 (1964; originally used in the M16), Soviet 5.45×39mm M74 (1974; used in the AK-74, which replaced the AKM), Belgian SS109 / 5.56×45mm NATO (1980; used in most AR-15 systems), and the Chinese 5.8×42mm (1987; used in the QBZ-95) allow a soldier to carry more ammunition for the same weight compared to their larger and heavier predecessor cartridges, have favourable maximum point-blank range or "battle zero" characteristics and produce relatively low bolt thrust and free recoil impulse, favouring lightweight arms design and automatic fire accuracy.